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Arbeitsgruppe Thomas Karonitsch

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Fibroblast-like synoviocytes (FLS) are major pathogenic cells in inflammatory joint diseases, such as rheumatoid arthritis (RA). Our group aims to unfold the mechanisms that drive FLS activation in inflammatory joint diseases. We focus on inflammatory and metabolic pathways (e.g. mTOR pathway) that are critical for the inflammatory response in FLS.

We also study how FLS interact with immune cells (e.g. T-cells) in order to disrupt the pathogenic crosstalk between these cells. Using molecular and high-throughput techniques, such as next-generation sequencing (NGS), we gain novel insights into the inflammatory response in FLS.  This will pave the way for novel therapeutic concepts to treat inflammatory joint diseases, such as RA.